Provided substantive evidence (from ecological studies conducted in Argentina and Chile) that arsenic is a potent cause of human bladder cancer and lung cancer.
Showed that epidemiological and human experimental data do not support the hypothesis that methylation protects against low dose arsenic effects.
Showed that with exposure to water containing around 600 ug/L of arsenic, 1 in 10 adult deaths may be due to arsenic-caused cancers, one of the highest environmental cancer risks ever reported in a large population.
Identified a dose-response relationship between arsenic exposure and bladder cell micronuclei, a genotoxic marker of effect, and changes in the frequency of micronuclei after exposure to arsenic is reduced.
Identified the dose-response relationship between arsenic concentration in well water in India and the occurrence of keratoses and hyperpigmentation.
Completed two bladder cancer case-control studies, one in Argentina and one in California/Nevada, showing modest increases in bladder cancer related to potential exposure to arsenic in wells, but only in smokers.
University of California, Berkeley ~ School of Public Health ~ 140 Warren Hall MC7360 ~ Berkeley, CA 94720-7360
