PH C102: Bacterial Pathogenesis (3 units)
This course for upper division and graduate students will explore the molecular and cellular basis of microbial pathogenesis. The course will focus on model microbial systems which illustrate mechanisms of pathogenesis. Most of the emphasis will be on bacterial pathogens of mammals, but there will be some discussion of viral and protozoan pathogens. There will be an emphasis on experimental approaches. The course will also include some aspects of bacterial genetics and physiology, immune response to infection, and the cell biology of host-parasite interactions. Also listed as MCB C103 and Plant Biology C103.
(Spring) Portnoy
PH 162A: Public Health Microbiology (3 units)
Prerequisite: One year each of college-level biology and chemistry.
Introduction to properties of microorganisms; their relationships with humans in causing infectious diseases and in maintaining health. With 162L, staisfies most requirements for a laboratory course in microbiology. May be taken without 162L.
(Fall) Buehring, (Summer) Danielson
PH 162L: Public Health Microbiology Laboratory (1 unit)
Prerequisite: One year each of college-level biology and chemistry.
Laboratory to accompany 162A. Must be taken concurrently with 162A.
(Fall , Summer) Loretz
PH 256: Molecular and Genetic Epidemiology (3 units)
Review of genetic epidemiology with emphasis on novel methods of molecular biology and genetics, including role of genetic factors in human disease and their interaction with environmental and cultural factors, population polymorphisms, role of inbreeding, and epidemiology of multifactorial diseases. Molecular epidemiology and the use of biological markers will be explored with the goal of illustrating both the power and limitations of biomarkers currently available for epidemiological research. Laboratory work and Internet demonstrations will provide students with hands-on experience with modern methods of molecular epidemiology.
(Fall) Barcellos, Holland, Sensabaugh
PH 260A: Principles of Infectious Disease, Part I (4 units)
Prerequisite: Upper division course preparation in biology, molecular biology, immunology, or consent of instructor.
This course presents general principles of microbial interactions with humans that result in infection and disease. Common themes are developed using examples of viral, bacterial, and parasitological pathogens that exemplify mechanisms of infectious disease. The epidemiology, pathogenesis, host immune response, diagnosis, treatment, and control will be presented for each infectious disease discussed.
(Fall) Riley, Swartzberg
PH 260B: Principles of Infectious Disease, Part II (4 units)
Prerequisite: 260A or consent of instructor.
A critical analysis of the host-parasite interactions that occur and infection of humans with various infectious disease agents, including representative nematodes, trematodes, cestodes, protozoa, fungi, bacteria, viruses, and prions.
(Spring) Swartzberg, Riley
PH 260C: Infectious Disease Laboratory (2,4 units)
Prerequisite: 260A or consent of instructor.
Module 1: Practice in standard techniques for the isolation, identification, and characterization of infectious agents; laboratory safety.
Module 2: Application of molecular methods to the identification and characterization of infectious agents, vectors, and hosts.
(Spring) Sensabaugh, Loretz
PH 260E: Molecular Epidemiology of Infectious Diseases (2-3 units)
Prerequisite: 150A.
The course will cover general principles and practical approaches in the use of molecular laboratory techniques to address infectious disease epidemiologic problems. It is designed for students with experience in the laboratory or in epidemiology, but not both. The principles to be discussed will include the use of molecular techniques in outbreak investigations, characterizations of dynamics of disease transmission, identifying vehicles, quantifying attributable risks in sporadic infections, refining data stratification to assist case-control studies, distinguishing pathovars from non-pathogenic variants of organisms, doing surveillance, and identifying genetic determinants of disease transmissions. 3 units if a five page paper is completed.
(Fall) Riley
PH 260F: Infectious Disease Research in Developing Countries (2 units)
The objective of this course is to provide M.P.H. and Ph.D. students with an appreciation and understanding of the complex issues involved in conducting scientific, laboratory-based investigation in developing countries. We will discuss the many obstacles to establishing and sustaining research projects, such as poor infrastructure, insufficient financial and material resources, and lack of scientific information and interaction. More importantly, we will identify innovative solutions to overcoming these obstacles. The first half of the course will consist of presentations by U.S. and developing countries investigators who have long-term research experience in Latin America, Asia, and Africa. We will also discuss related issues such as ethical considerations, equitable collaborations, and research capacity strengthening. During the second half of the course, students will give presentations on topics of their choice.
Offered odd-numbered years. (Spring) Harris
PH 261: Advanced Medical Virology (3, 4 units)
Prerequisites: An understanding of the general principles of epidemiology, biochemistry, molecular biology, and microbiology will be assumed. 260A and 260B will be desirable.
This course attempts to provide a critical evaluation of the current studies of medically important viruses related to human diseases. Particular emphasis will be addressed on how to determine whether and what viral pathogens cause outbreaks and the recent advances on understanding and treatment of HIV and AIDS. This course is intended for graduate students interested in a comprehensive understanding of the molecular and biological basis of several human viruses and how they are discovered clinically and studied recently.
Four units of credit given to doctoral students who write a research proposal on a topic other than that proposed for their dissertations.
(Spring) Botchan, Liu, Penhoet
PH 262: Molecular and Cellular Basis of Bacterial Pathogenesis (3 units)
Prerequisite: 260A, 260B or consent of instructor.
This course for graduate students will explore the molecular and cellular basis of bacterial pathogenesis. The emphasis will be on model bacterial pathogens of mammals. The course will also include some aspects of bacterial genetics and physiology, immune response to infection, and the cell biology of host-parasite interactions. Students enrolled in 262 will also be required to attend a weekly discussion of the primary literature, both current and classic. Each student will be required to present one paper.
(Spring) Portnoy
PH 264: Current Issues in Infectious Diseases (2 units)
Prerequisites: 2nd year ID MPH students only. Formerly 264A-264B.
Examination of scientific, social, and policy dimensions of issues involving infectious diseases. Students select one topic for in-depth analysis and present findings in a public debate. Topics vary from year to year.
(Fall) Sensabaugh
PH 265: Molecular Parasitology (3 units)
Prerequisite: Upper division courses in molecular biology, parasitology, biochemistry, immunology, microbiology, or consent of instructor. Familiarity with reading primary research is recommended.
Advanced course in the molecular aspects of parasite immunology, molecular biology, genetics, biochemistry, and genomics. For each parasite, the following areas will be covered: biology; disease spectrum; epidemiology; pathogenesis, immunology; and vaccine development. The lectures will focus on "state-of-the-art" research in relation to molecular mechanisms of pathogenesis, parasite adaptations for survival within the host, and strategies for drug and vaccine development and disease control and prevention. Course content will rely heavily on current literature.
Offered odd-numbered years. (Fall) Harris
PH 266: Viruses and Human Cancer (3 units)
Prerequisite: Course in basic virology or microbiology.
Topics include the molecular biology of tumor viruses; mechanisms of viral carcinogenesis; vs. characteristics of virally transformed cells; the epidemiology, pathology, diagnosis, treatment, and prevention of virally caused cancers; problems of proving the etiology of virally caused cancers. A term paper or grant proposal is required.
Offered even-numbered years. (Spring) Buehring
PH 266A: Foodborne Diseases (2 units)
Prerequisite: Basic knowledge of microbiology.
This course will cover public health, microbiological, social, and economical issues related to foodborne disease. Three areas will be explored: 1) categories, clinical manifestations, and disease processes of foodborne lines; 2) etiological agents causing foodborne illness; 3) investigation and prevention of foodborne illness. The course will discuss different types of foodborne disease, clinical manifestations, and the interactions between etiological agents (pathogens and non-pathogens) and human hosts. We will cover pathogens that are the most frequently associated with foodborne illness including bacterial and viral pathogens such as Salmonella, E coli, hepatitis viruses and Norwalk-like gastroenteritis viruses. We will also study non-pathogen agents such as heavy metal, pesticide, and toxic chemicals. Furtermore, the course will discuss how to identify the etiological agents in outreaks and possible measures that can be taken to minimize the risk to the public including vaccines and education. Finally, we will explore the social and economic issues involved in the food production, distribution, and consumption that contribute to foodborne diseases.
(Fall) Lu
PH 275: Current Topics in Vaccinology (2 units)
Prerequisite: 260A and basic immunology course.
This is an advanced infectious disease course designed to cover issues related to the biological aspects of vaccinology. It will begin with discussions related to the concepts of correlates of protection, new understanding of cell-mediated and humoral immune response, and mucosal immunity. Then, topics related to the latest drevelopments in recommbinant vaccine technology, vaccine delivery stystems, "naked DNA" vaccines, "designer" vaccines ("edible vaccines"), and the status of AIDS vaccine as a paradigm for new vaccine development will be covered. Each session will begin with a didactic lecture on topics outlined in the syllabus. This will be followed by a 10-15 minute discussion based on published studies assigned for the week. Two students will lead the discussion at each section. A satisfactory letter grade or a passing grade will be based on participation in class discussions, presentation, and a five-page paper.
Offered odd-numbered years. (Spring) Riley
PH 276: Integrity in the Conduct of Research (2 units)
This course presents an analysis of the core issues for the responsible and ethical conduct of research in biomedical sciences. Issues pertinent to standards and responsibilities of research conduct, authorship and publication practices, peer review and privileged information, conflicts of interest, collaboration, and use of animals and humans in research will be defined and explored. The legal and regulatory structures, definitions of misconduct and process of misconduct investigations will be presented.
Offered odd-numbered years. (Fall) Stephens
PH 291A: Preparation for Public Health Practice (1 unit)
Formerly PH 291.
A series of skills-based workshops designed to introduce the student to specialized skills needed in the public health workplace. These workshops are designed to complement the core curriculum of the School of Public Health and are selected based on regular feedback from faculty, public health practioners, and students. Workshop facilitators include consultants, CPHP field supervisors, and public health practitioners with expertise in the subject. This course or series of workshops is open to all MPH and DPh students. The student selects from a list of 1 1/2 and 2 hour workshops total 1 unit equal to 15 hours of class time, plus readings that are assigned for many of the workshops. Workshop topics have included writing for publication, for the media, or for policymakers (3 separate workshops); management styles; cost-effectiveness and cost-benefit analysis techniques; oral presentations; diversity in the workplace; negotation and conflict resolution; tools for financial planning and budgeting; using Powerpoint; strategic planning; and legislation in action.
(Fall, Spring) Staff
PH 292: Seminars for M.P.H. Students (1-4 units)
Current topics and special issues in the health field.
(Fall, Spring) Staff
PH 293: Doctoral Seminar (1-4 units)
Discussion and analysis of dissertation research projects, as well as of conceptual and methodological problems in planning and conducting health research.
(Fall, Spring) Staff
Current Offerings for PH 293:
“Infectious Diseases & Immunity”
Infectious Diseases Research Design and Methodology. One seminar hour per week. This course is intended for doctoral students in Infectious Diseases – advanced MPH students may enroll by consent of instructor. Biochemical, molecular, and genetic theory, design and methodologies used in research of the biology and pathogenesis of infectious agents will be explored in the context of recent advances in microbial biological processes. Students must also attend the Microbial Biology seminar that serves as the basis for discussion.
(Fall 2007, Spring 2008) Stephens
“Current Research in Infectious Diseases”
(Fall 2007, Spring 2008) Staff
“Representations of Infectious Diseases in Literature and the Arts”
Infectious diseases have been used in literature and the arts as plot devices to advance narrative flow, as backdrops for the stage on which the protagonists act, and as metaphor connoting broader concepts. Whatever the use, the representations of disease often reflect the social and moral notions of the time as well as varying degrees of medical awareness. The concept of "plague," for example, has taken many different forms over the two thousand years from Oedipus to Camus. Many of the connotations associated with infectious diseases in past times carry over to the present in both popular thought and public health. The objective of this seminar is to explore some of these representations from Greek theatre to the present in literature, drama, and art. Students will make presentations based on readings and viewings. (may also be taken as PH 292)
(Fall 2007) Sensabaugh
“Infectious Diseases as Portrayed in Film”
This seminar will explore how infectious diseases have been depicted in film throughout history from different parts of the world. Film, from its earliest inception, has played an important role in influencing human knowledge as well as fear, prejudice, and stigma regarding infectious diseases. Different countries portray diseases through their own distinct cultural perspectives. Within a country, time alters the way infectious diseases are viewed and these views reflect the mainstream prejudices and outlook societies had at the time. This seminar is designed to introduce not only how film has influenced the general public’s perception and understanding of infectious diseases, but also some of the film’s greatest directors around the world, including Satyajit Ray, Akira Kurosawa, and Abbas Kiarostami. Discussions will center around scientific accuracy of the portrayal of diseases, the impact film had on society’s perception, and how our discussions relate to our understanding of the infectious disease issues that dominate the contemporary world. (may also be taken as PH 292)
(Spring 2008) Riley
PH 295: Seminars (1-4 units)
(Fall, Spring) Staff
PH 296: Special Study (1-10 units)
Designed to permit any qualified graduate student to pursue special study under the direction of a faculty member.
(Fall, Spring) Staff
PH 297: Field Study in Public Health (1-12 units)
Supervised experience relevant to specific aspects of public health in off-campus organizations for graduate students. Regular individual meetings with faculty sponsor and written reports required.
(Fall, Spring) Staff
PH 298: Group Study (1-8 units)
(Fall, Spring) Staff
PH 299: Independent Research (1-12 units)
Independent study and research.
(Fall, Spring) Staff
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